教科研成果 | 主持或参与的代表性科研项目: 1.长治医学院博士启动项目,项目名称:靶向PD-1/PD-L1轴咔唑系列小分子肿瘤免疫治疗药物开发及其作用机制研究,项目编号:2024BS01,30万元,起止时间:2024.6-2026.12,在研,主持 2. 国家自然科学基金面上项目,22177105,靶向PD-L1蛋白的抗神经母细胞瘤小分子到PROTAC分子候选药物发现和作用机制,2022/01-2025/12,60万元,在研,参与 3. 国家自然科学基金面上项目,21877101,免疫调控PD-1/PD-L1信号通路的小分子发现及抗肿瘤活性研究,2019/01-2022/12,67.5万元,已结题,参与 近五年发表的代表性学术论文: (1)Hua Zhang, Shijia Zhou, Jacek Plewka, Caiyun Wu, Mengyu Zhu, Qimeng Yu, Bogdan Musielak, Xiao Wang, Annoor Awadasseid, Katarzyna Magiera-Mularz*, Yanling Wu*, Wen Zhang*. Design, synthesis and antitumor activity evaluation of 2-arylmethoxy-4-(2,2'-dihalogen-substituted bipheyl-3-ylmethoxy) benzylamine derivatives as potent PD-1/PD-L1 inhibitors. J. Med. Chem. 2023, 66, 15, 10579-10603. (2)Hua Zhang#, Shi-Jia Zhou#, Chen-Feng Shen#, Yong-Nan Zhou, Cai-Yun Wu, Meng-Yu Zhu, Qi-Meng Yu, Annoor Awadasseid, Yan-Ling Wu* & Wen Zhang*. (2023) PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathway. J. ENZYM. INHIB. MED. CH., 2023, VOL. 38, NO. 1, 2230388. DOI:10.1080/14756366.2023.2230388. (3)Hua Zhang, Mengyu Zhu, Annoor Awadasseid, Wen Zhang*. A Review on The Anticancer Activity of Carbazole-based Tricyclic Compounds. Current Medicinal Chemistry. August, 2023. DOI: 10.2174/0929867331666230825104254. (4)Qiong Huang, Xiao Wang, An Chen, Hua Zhang, Qimeng Yu, Chenfeng Shen, Annoor Awadasseid, Xiaoyin Zhao, Xuqiong Xiong, Yanling Wu*, Wen Zhang*. Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex. Biochemical Pharmacology. Volume 201, July 2022, 115062. https://doi.org/10.1016/j.bcp.2022.115062. 发明专利: 张文*; 张华; 吴艳玲; 朱孟宇; 周诗佳. 一种氟代联苯甲基间苯二酚醚类衍生物、其制备方法和应用. CN202111475689. 2023-4-4. |